Bulldog Health
Bulldog Breeds
Bulldog Health:Clinical characteristics and inheritance of idiopathic epilepsy in Vizslas.
Medical record, seizure survey, and telephone interview information was obtained for 29 Vizslas with idiopathic epilepsy (IE), 74 unaffected siblings, and 41 parents to determine the common clinical characteristics and most likely mode of inheritance. IE was diagnosed on the basis of the age of seizure onset, laboratory results, and neurologic examination findings. Computerized tomography (CT) or magnetic resonance imaging (MRI) scan with cerebrospinal fluid (CSF) analysis was required for the inclusion of dogs with an age of seizure onset of < 6 months or > 5 years. Simple segregation analysis was performed with an ascertainment correction and chi-square analysis. IE appeared to be familial in these pedigrees, with 79% of affected Vizslas exhibiting partial onset seizures. Partial seizure signs included a combination of limb tremors, staring, pupillary dilatation, or salivation without loss of consciousness in > 50% of the dogs with partial signs. The estimated segregation frequency of P = .22 (95% CI, P = .08 to .36) was consistent with autosomal recessive inheritance; however, polygenic inheritance could not be excluded as a possibility. Simulated linkage with FASTSLINK estimated that the average logarithm of odds (LOD) score would be 3.23 with a 10-centimorgan (cM) whole-genome scan for these families, indicating that these families would be useful for a whole-genome scan to potentially find the chromosomal segment(s) containing the epilepsy gene or genes. We conclude that IE in Vizslas appears to be primarily a partial onset seizure disorder that may be inherited as an autosomal recessive trait.
Department of Small Animal Clinical Sciences, University of Minnesota, College of Veterinary Medicine, St Paul, MN 55108, USA.
Patterson EE, Mickelson JR, Da Y, Roberts MC, McVey AS, O'Brien DP, Johnson GS, Armstrong PJ.
The Original Bulldog Club ->> The Bulldog Club of Milan ->>To promote and encourage the Breeding of Pure Bulldogs in all of the World, but more especially In the provinces of England, to Ireland, and in Scotland, in Italy, in Lombardy and in Milan.
Honorary President, Ever and Forever, Mrs. D.N. and Mr. Les Thorpe. Bulldog Club, creato per celebrare la incredibile nascita proprio a Milano, per merito esclusivo di Tuffnuts Bulldogs, in collaborazione con il The Bulldog International Research Center e con Ocobo Show Bulldogs, di quelli che, secondo i più profondi studi mondialmente dimostrabili, risulterebbero essere i più diretti discendenti e, quindi, i legittimi eredi di Rosa, il capostipite della Razza Bulldog, con genealogia integralmente inglese, Lincolnshire, Tuffnuts Ocobo. Il Club si è formato, infatti, nel Dicembre 2004 alla nascita di Tuffnuts Snow Angel Tuffnuts, dedicata al Maggiore L.A. Jackson ed a Dr. Les Cotton, il secondo Original Pure Breed Bulldog, nato a Milano ed in Italia dopo Tully, nato nel 2000, sempre nell ' Allevamento Tuffnuts Snow Angel. Per supportare la razza e tutti coloro che possiedono un Bulldog Inglese. Cucciolate disponibli, affidamento bulldogs, problemi di salute, riproduttori disponibili, etc..Il primo Club che si pone l'obiettivo di selezionare ed allevare anche il Bulldog Originale di Razza Pura, come era fino all' inizio del 20° secolo, con una genealogia completamente inglese, discendente dai più famosi Campioni della Storia.
